N.C.S.R. "Demokritos"


Department of Materials Science

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Biomedical applications of ferromagnetic nanoparticles

In the research activity of biomedical applications we study both therapeutic and diagnostic opportunities of ferromagnetic iron oxide nanoparticles such as blood purification methods and magnetic resonance imaging. For instance the concept of Magnetically Assisted Haemodialysis (MAHD) is based on the preparation of Ferromagnetic Nanoparticle-Targeted Binding Substance Conjugates (FN-TBS Cs). TBS must have high affinity for specific Target Toxin (TT). The FN-TBS Cs are administered to the patient (by an intravenous injection) timely prior to the MAHD session. Thus, as they circulate in the bloodstream they bind with the TT (see schematic Fig. 1A). During MAHD the FN-TBS-TT complex is removed by means of a “magnetic dialyser” (MD) that is installed to the dialysis machine in series to the conventional dialyser. We have performed comparative mock dialysis experiments on MAHD and conventional HD by using bare and albumin conjugated Fe3O4 as FN-TBS Cs, homocysteine as a model TT, and an array of permanent magnets as a MD (see Figs. 1B-1D). These results proved that MAHD is more efficient than conventional HD by 60% on the removal of homocysteine. Very recently we have examined the biocompatibility of bare and albumin conjugated Fe3O4 with human blood cells (see Figs. 2A and 2B). We observed that the employed FNs do not interfere with the most abundant type of blood cells, namely red blood cells.

For more information on this activity contact Dr. Dimosthenis Stamopoulos densta@ims.demokritos.gr Institute of Materials Science NCSR Demokritos, 15310, Aghia Paraskevi, Athens, GREECE.

Department of Materials Science, N.C.S.R. "Demokritos", 153 10 Aghia Paraskevi, Attiki, phone: +30 210 6503381, fax: +30 210 6519430
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